All posts by Sumana Rao

Don't worry about the people in your past; There's a reason they didn't make it to your future.
Chagas Disease Testing

Chagas Disease Testing

This parasitic infection, transmitted by triatomine bugs, is a concern in certain regions. Some blood banks screen for Chagas disease to prevent transmission.

 

Testing for Chagas disease typically involves a blood test to detect antibodies to the parasite Trypanosoma cruzi, which causes the disease. The most common method for diagnosing Chagas disease is through serological tests. These tests look for antibodies in the blood that the immune system produces in response to the presence of the Trypanosoma cruzi parasite.

 

It’s important to note that Chagas disease has acute and chronic phases, and the tests may be more accurate during specific phases of the infection. Additionally, the availability of specific tests and testing methods may vary by location and healthcare facility.

 

Image credit: Photo by Karolina Grabowska: https://www.pexels.com/photo/vials-of-blood-on-medical-diaper-4230623/ (cc by 0)


Author: Sumana Rao | Posted on: September 7, 2023
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West Nile Virus Infection Testing

West Nile Virus Infection Testing

In regions where West Nile Virus is prevalent, blood banks may screen for the virus to prevent its transmission through blood transfusions.

 

West Nile Virus (WNV) is a mosquito-borne virus that can infect humans and animals.  West Nile Virus is primarily transmitted to humans through the bite of infected mosquitoes. Mosquitoes become infected when they feed on infected birds, which serve as the primary reservoir of the virus. Many people who are infected with West Nile Virus do not develop any symptoms, while others may experience mild to moderate symptoms, including fever, headache, body aches, joint pain, vomiting, diarrhea, or rash.

 

According to American red cross -Following the introduction of blood donation screening in 2003 through the end of 2018, there have been 15 cases of documented WNV-transfusion transmission from screened blood; all are believed to be due to donations having very low levels of virus. This translates to a risk of about 1 per 84 million donations for the Red Cross overall (or 1 per 35 million during the summer transmission season).

 

Image credit: Photo by Charlie-Helen Robinson: https://www.pexels.com/photo/blood-samples-in-test-tubes-6622519/ (cc by 0)


Author: Sumana Rao | Posted on:
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Syphilis Infection Testing

Syphilis Infection Testing

 A blood test is used to detect the bacterium that causes syphilis, a sexually transmitted infection. Positive results may result in donor deferral.

 

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. It can also be transmitted from an infected mother to her unborn child during pregnancy or childbirth, which is known as congenital syphilis. Syphilis has several stages, and if left untreated, it can lead to serious health complications.

 

Screening for syphilis is performed using a qualitative test that detects the presence of antibodies to the spirochete (corkscrew-shaped bacterium), Treponema pallidum, by an automated agglutination assay based on specific pattern recognition. Confirmation is performed using another serologic test for total antibodies, an EIA, as well as a test for reagin (a protein-like substance that is present during acute infection and for several months following resolution of infection).

 

Image credit: Werindia.com


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Hepatitis B and C Virus Testing

Hepatitis B and C Virus Testing

These tests identify the presence of hepatitis B and C viruses, both of which can lead to liver disease. Positive results often lead to donor deferral.

 

Hepatitis B and Hepatitis C are two distinct types of viral hepatitis, which are liver infections caused by different viruses. They share the name “hepatitis” because they both primarily affect the liver, but they have different modes of transmission, characteristics, and treatments.

 

According to American Blood cross : HBV DNA and HBsAg are the first viral markers to circulate in an individual infected with HBV. Anti-HBc appears in the blood of individuals infected with HBV one to four weeks after the appearance of HBsAg, and at the onset of symptoms for those adults who develop symptoms (5% or less). The tests used for blood donor screening are the GS (Genetic Systems) HBsAg EIA 3.0, a qualitative ELISA for the detection of HBsAg, and the Ortho HBc ELISA for the qualitative detection of antibodies to HBV core antigen (anti-HBc) in human serum and plasma samples.

 

Image credit: Hepatitis c by Nick Youngson CC BY-SA 3.0 Pix4free


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Testing For HIV Human Immunodeficiency Virus

Testing For HIV Human Immunodeficiency Virus

This test checks for the presence of the virus that causes AIDS. Donors who test positive for HIV are typically deferred from donating blood.

 

Testing for Human Immunodeficiency Virus (HIV) in blood donors is a critical component of blood safety protocols. HIV is the virus that can lead to Acquired Immunodeficiency Syndrome (AIDS). Screening blood donors for HIV helps ensure that the donated blood supply is safe for transfusion recipients.

 

According to American Blood cross: Blood donation screening for HIV-1, the causative agent of AIDS began with antibody testing in 1985. Many improvements in testing have occurred, including the detection of a second HIV agent (HIV-2 in 1992). The test used for blood donor screening is the GS (Genetic Systems) HIV-1/HIV-2 PLUS O EIA for the simultaneous qualitative detection of anti-HIV 1 (groups M and O) and/or HIV-2 in human serum or plasma. A duplex NAT was introduced for HIV/HCV RNA detection in September 1999 and updated to include the detection of HBV DNA in June 2009 and HIV-2 RNA detection in July 2020.

 

Image credit: Hiv testing by Nick Youngson CC BY-SA 3.0 Pix4free


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Blood Safety - Blood Donations Are Screened For Infectious Diseases

Blood Safety – Blood Donations Are Screened For Infectious Diseases

Blood donation organizations and blood banks have specific protocols and tests in place to ensure that donated blood is safe for recipients. Generally, every unit of blood is tested to identify the donor’s blood group (O, A, B or AB) and Rh type, and screened for atypical or unusual red cell antibodies. There are a few more tests that are carried out to make sure that donated blood is safe to transfer.  These tests are essential for identifying potential infections and diseases that could be transmitted through blood transfusions.

 

While the exact tests may vary by location and organization, here are some common tests conducted to qualify blood donors for multiple diseases:

 

1.       HIV (Human Immunodeficiency Virus)

2.       Hepatitis B and C

3.       Syphilis

4.       West Nile Virus

5.       Chagas Disease.

6.       Malaria

7.       Cytomegalovirus (CMV)

8.       HTLV (Human T-cell Lymphotropic Virus)

9.       Zika Virus

10.   Bacterial Contamination

 

It’s important to note that blood banks and donation organizations have strict guidelines and eligibility criteria that potential donors must meet. These criteria include factors such as recent travel history, medical conditions, and other potential risk factors for disease transmission. Donors who do not meet these criteria or who test positive for certain infections are typically deferred from donating blood to protect the safety of both donors and recipients.

 

References:

https://www.redcrossblood.org/

https://www.who.int/

Blood Safety Basics | CDC

https://www.mskcc.org/

Image credit: https://pxhere.com/en/photo/1649335 (CC by 0)

Testing For HIV Human Immunodeficiency Virus

Testing For HIV Human Immunodeficiency Virus

Hepatitis B and C Virus Testing

Hepatitis B and C Virus Testing

Syphilis Infection Testing

Syphilis Infection Testing

 

West Nile Virus Infection Testing

West Nile Virus Infection Testing

 

Chagas Disease Testing

Chagas Disease Testing

Testing For Malaria

Testing For Malaria

Testing For Cytomegalovirus CMV

Testing For Cytomegalovirus CMV

 

HTLV -Human T-cell Lymphotropic Virus Presence Test

HTLV -Human T-cell Lymphotropic Virus Presence Test


Author: Sumana Rao | Posted on:
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AI avatar for communication

AI Technology and Brain Implant Helps Woman with Stroke to Speak After 18 years

Her name is Ann. She suffered a brainstem stroke at the age of 30 and it left her deeply paralyzed. The reason for the stroke is still mysterious. The condition resulted in loss of control of all muscles in her body. Ann was unable to breathe. Ann is 47 years now. After 18 years of the injury, even though she cannot speak verbally on her own, thanks to AI technology, Ann can communicate and able to speak through an avatar using AI technology that translates her brain signals into facial expression along with her speech!

Speech is the ability to express ideas and thoughts through spoken words. Speech loss after an injury eventually can impair communication and can cause social isolation.

Until recently, patients were able to communicate slowly by relying on slow speech synthesizers. These speech synthesizers spelling out words by using eye tracking or facial movement. Using this till recently Ann was able to communicate using this movement tracking technology where she can select letters of up to 14 words a minute. Even though this method is useful, communication is highly limited. With the new technology- the brain computer interfaces (BCIs) could transfer lives of people who are unable to speak like Ann due to strokes or ALS (Amyotrophic lateral sclerosis). 

How Ann is able to speak and communicate more now?

Tiny electrodes implanted on Ann’s brain surface to detect electrical activity in the part of the brain that controls speech and face expressions and movements. Signals translated directly to digital avatar. Avatar expresses speech and facial movement of all sorts – frustration, smile, frowning, surprise, laugh etc.

This research work carried out at University of California, San Fransisco (UCSF).  According to Prof Edward Chang, who is the lead of this research work “our goal is to restore full, embodied way of communicating, which is really the most natural way for us to talk with others. These advancements bring us much closer to making this a real solution for patients” Research team implanted a paper-thin rectangle of 253 electrodes on Ann’s brain surface which is critical for the speech. These electrodes intercepted the brain signals.  Ann worked with a research team to train the AI algorithm to detect brain signals for different speech sounds using various phrases repeatedly.

Ann’s voice was personalized in avatar by using her wedding speech. The AI system learned 39 distinctive sounds and Chat GPT- style language model was used for translating the signals into sentences. The test run had 500 phrases and it generated brain to text at a rate of 78/ minute compared to natural conversation where 110-150 words/ minutes spoken. The next step in this innovation is to create a wireless version of the BCI to implant beneath the skull.

According to researchers’ accuracy, speed and sophistication of this technology suggests that that this AI Avatar speech system is now can be used in practical purposes for patients.

D. David Moses, one of the co -author of the research said, “Giving people the ability to freely control their own computers and phones with this technology would have profound effects on their independence and social interactions.

Says Ann “My brain feels funny when it hears my synthesized voice. It’s like hearing an old voice. I want patients to see me and know that their lives are not over. I want to show them that disabilities don’t need to stop us or slow us down,” Ann is currently helping researchers at UC San Francisco and UC Berkeley develop new brain-computer technology that could one day allow people like her to communicate more naturally through a digital avatar that resembles a person.

For more on this innovation see this video: How a Brain Implant and AI Gave a Woman with Paralysis Her Voice Back – YouTube

References:

https://www.universityofcalifornia.edu/

https://www.nature.com/

https://regina.ctvnews.ca/

https://www.technologyreview.com/

Image credit: UCSF -University of California, San Fransisco


Author: Sumana Rao | Posted on: August 28, 2023
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